Rong Fan, who has made significant contributions to biotechnology innovation and precision medicine, particularly in the areas of single-cell and spatial omics and cancer immunotherapy, has been appointed Harold D. Hodgkinson Professor of Biomedical Engineering.
He is a faculty member in the Department of Biomedical Engineering at the Yale School of Engineering and Applied Science. He also has an appointment in the Department of Pathology at Yale School of Medicine.
Fan joined the Yale faculty in 2010 after a postdoctoral fellowship at the California Institute of Technology. Since establishing his independent research group at Yale, he is widely regarded as an international expert in the field of single-cell and spatial omics analysis, evidenced by his recent publications and prestigious awards including patents and Packard Fellowships. is exemplified by his recognition with for Science and Engineering, an NSF Career Award, and elected to the American Institute of Biological and Medical Engineers (AIMBE), the Connecticut Academy of Science and Engineering (CASE), and the National Academy of Inventors (NAI).
An expert in a wide range of diverse fields – including bioanalytical chemistry, microengineering, proteomics, immunobiology, cancer biology and translational medicine – he has demonstrated an impressive track record as an academic inventor, having successfully developed a number of transformative and innovative technologies has been done. Broad and far-reaching implications in many scientific fields (eg, bioengineering, stem cell science, immunology, cancer biology, neuroscience, and precision medicine). They have demonstrated an ability to break into new territory, identify critical problems, and develop tools with far-reaching impact. He has also demonstrated an exceptional ability to take technology innovation from the lab to the clinic and from proof-of-concept demonstration to commercialization.
During his career at Yale, Fan has invented many innovative and transformative techniques in single-cell and spatial omics analysis, and has demonstrated a unique talent for inventing new technologies to advance human genomics and precision medicine. Have done For example, his invention of single-cell high-plex protein secretion profiling to monitor cancer immunotherapy has been widely adopted by pharma companies in the immuno-oncology space. In 2017, the technology won first prize in Scientific Magazine’s Top 10 Innovations, and won the Fierce Bioinnovation Award in the same year. The US patent for this technology was granted fast-track approval by the USPTO and licensed to Isoplexis, a Yale spinout company; Products commercialized by this company have been used by over 100 cancer centers and pharmaceutical companies including all of the world’s top 15 leading pharmaceutical companies.
He also invented a portable microdevice for single-cell sequencing applications, which led to the formation of a second company, Singletron Biotechnology, based on his patent. More recently, he pioneered a number of spatial omics technologies, including spatial multi-omics sequencing and the first and only spatial indigenous sequencing technology, which has become the foundation of AtlasExomics, a third company founded in 2020 that has attracted significant attention. science instrument companies, the pharmaceutical industry and biotech investors.
Furthermore, Fan is an enthusiastic and valuable mentor to young inventors. His graduate students and postdocs are often co-inventors on patent applications, and have gone on to have inventive careers of their own.
He received his BS and MS from the University of Science and Technology of China, and his Ph.D. from the University of California, Berkeley.